Thermo Fisher Scientific DCTN2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis, X. tropicalis, Chicken, and Bovine

Target Information

This gene encodes a 50-kDa subunit of dynactin, a macromolecular complex consisting of 10–11 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in various cellular processes, including:

• ER-to-Golgi transport
• Centripetal movement of lysosomes and endosomes
• Spindle formation and chromosome movement
• Nuclear positioning and axonogenesis

This subunit is present in 4–5 copies per dynactin molecule and contains three short alpha-helical coiled-coil domains that may mediate association with itself or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and help stabilize its position.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.