Thermo Fisher Scientific MASP2 Monoclonal Antibody (C3)

Applications

Western Blot (WB)

• Tested Dilution: 0.5–5 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5–30 µg/mL

Product Specifications

Target Information

Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain.
MBL is a key component in immune response as it can directly trigger neutralization of invading microorganisms by an antibody-independent mechanism. Mutations of human MBL are associated with immunodeficiency due to reduced ability to initiate complement fixation.

In humans, three types of MBL-associated serine proteases — MASP-1, MASP-2, and MASP-3 — and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3, an alternatively spliced product from the MASP-1 gene, may function to inhibit MASP-2 by competing for MBL binding and inhibiting MASP-2 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.