Thermo Fisher Scientific POLR3E Polyclonal Antibody
Rabbit polyclonal antibody targeting human POLR3E for WB and IP applications. Recognizes residues 475–525 of RNA polymerase III subunit E. Supplied as liquid at 1 mg/mL, stored at 4 °C. For research use only.
- 카탈로그번호
- A303708Ax (2개 옵션)
- 판매단위
- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific POLR3E Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and 525 of Human Polymerase (RNA) III (DNA directed) Polypeptide E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a specific peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs. POLR3E is essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. It plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in innate immune response. POLR3E can sense non‑self dsDNA that serves as a template for transcription into dsRNA. The non‑self RNA polymerase III transcripts, such as Epstein–Barr virus‑encoded RNAs (EBERs), induce type I interferon and NF‑κB through the RIG‑I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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