Thermo Fisher Scientific LDHA Polyclonal Antibody
Thermo Fisher Scientific의 LDHA Polyclonal Antibody는 인간 LDHA 단백질을 특이적으로 인식하는 토끼 유래 IgG 항체입니다. IHC 및 ICC/IF에 사용 가능하며, 비보존제 상태로 제공되어 오염 방지를 위해 sodium azide 추가가 권장됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific LDHA Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human LDH-A/LDHA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at −20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2788511 |
Product Specific Information
- Preservative-free formulation.
- Recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
- Specificity: Human LDHA.
Target Information
Lactate dehydrogenase (LDH) is a key enzyme in the glycolytic pathway that converts pyruvate to lactate, coupled with NADH/NAD+ interconversion. In mammals, LDH is encoded by three genes:
- LDHA (M form, muscle)
- LDHB (H form, heart)
- LDHC (X form, testis)
Human LDHs share 84–89% sequence similarity and 69–75% amino acid identity. Five LDH isoenzymes exist depending on the M/H chain composition within the tetrameric structure.
LDHA expression is hypoxia-inducible and regulated by HIF1α transcriptional activity. LDHB is upregulated in many cancers. Mutations in the LDHA gene are associated with Glycogen Storage Disease 11 (GSD11).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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