Thermo Fisher Scientific Human IRAK1 Synthetic Peptide
인간 IRAK1 단백질의 C-말단 13 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-19855의 블로킹 펩타이드로 사용 가능. IL-1 수용체 신호전달 연구용. PBS 완충액(0.1% BSA, 0.02% NaN3) 내 액상 형태, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human IRAK.
PEP-0001 can be used as a blocking peptide with polyclonal antibody PA5-19855.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways.
It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK’s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation.
Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus.
This results in the transcriptional activation of type I IFN genes, which drive the cell into an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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