Thermo Fisher Scientific FARP2 Polyclonal Antibody
FARP2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. Protein A로 정제된 액상 항체이며, 고농도(1 mg/mL)로 안정적 저장 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human FARP2, amino acids 601–700 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FIR, is a 1,545 amino acid protein containing one FERM domain, one DH domain, and two PH domains.
It exists as two alternatively spliced isoforms abundantly expressed in brain, lung, and testis, as well as in embryonic hippocampal and cortical neurons.
FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and regulates neurite remodeling of embryonic neurons.
Sema3A binding to neuropilin-1 induces dissociation of FARP2 from plexin-A1, activating Rac GEF activity critical for axon repulsion and neuronal adhesion suppression.
Downregulation of FARP2 has been implicated in autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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