Thermo Fisher Scientific Human TACR3 Synthetic Peptide
인간 NK3R 중심부 18개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20392 항체의 블로킹 펩타이드로 사용 가능. Assay 의존적 사용. PBS(pH 7.2)와 0.1% BSA 함유, -20°C 보관.
- 카탈로그번호
- PEP0509
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human NK3R.
PEP-0509 can be used as a blocking peptide with polyclonal antibody PA5-20392.
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which act on three related but distinct seven transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin into circulation.
NK3R may be involved in learning and memory, as mice lacking this gene show cognitive deficits compared to normal mice. Although NK3R has been suggested to regulate vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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