Thermo Fisher Scientific Human TACR3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human NK3R.
PEP-0509 can be used as a blocking peptide with polyclonal antibody PA5-20392.

Target Information

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which act on three related but distinct seven transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin into circulation.
NK3R may be involved in learning and memory, as mice lacking this gene show cognitive deficits compared to normal mice. Although NK3R has been suggested to regulate vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.