Thermo Fisher Scientific HMCN1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500
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Product Specifications

Product Specific Information

Immunogen sequence:
LNATITDSPN SDTRIIRAKI TNVPRSLGSA MRKIVSILNP IYWTTAKEIG EAVNGFTLTN AVFKRETQVE FATGEILQMS HIARGLDSDG SLLLDIVVSG YVLQLQSPAE VTVKDYTEDY IQTGPGQLYA YSTRLFT

• Highest antigen sequence identity to orthologs:
  • Mouse: 89%
  • Rat: 90%

Target Information

Hemicentin-1 (HMCN1), also known as fibulin-6 (FIBL-6), is an extracellular protein belonging to the immunoglobulin superfamily.
HMCN1 consists of:

• von Willebrand A domain
• Tandem immunoglobulin modules
• Tandem EGF modules
• Fibulin carboxy-terminal module

Mutations in the HMCN1 gene may be associated with age-related macular degeneration.
Three alternative transcripts encoding different HMCN1 isoforms have been described.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.