Thermo Fisher Scientific ZNRF2 Polyclonal Antibody
Thermo Fisher Scientific의 ZNRF2 Polyclonal Antibody는 인간 ZNRF2 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot 및 IHC(P) 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: -
- View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: -
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZNRF2. Recombinant protein control fragment (Product #RP-108596) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792039 |
Product Specific Information
Immunogen sequence:
NSSSGPYGSQ DSVHSSPEDG GGGRDRPVGG SPGGPRLVIG SLPAHLSPHM FGGFKCPVCS KFVSSDEMDL HLVMCLTK
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, endosome, and cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, likely by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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