Thermo Fisher Scientific CLDN5 Monoclonal Antibody (OTI1G4), TrueMAB
CLDN5 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 면역세포염색(ICC/IF)에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 세포 간 밀착연접 연구 및 암 관련 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G4 |
| Immunogen | Full length human recombinant protein of human CLDN5 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The CLDN5 gene encodes a member of the claudin family, which are integral membrane proteins forming tight junction strands.
Tight junctions act as barriers preventing solute and water movement between epithelial or endothelial cells and are critical for maintaining cell polarity and signal transduction.
Differential expression of CLDN5 has been observed in various malignancies, including breast, ovarian, liver, urinary, prostate, lung, head and neck, and thyroid cancers.
Alternative splicing results in different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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