Thermo Fisher Scientific Cardiotrophin 1 Polyclonal Antibody
Cardiotrophin-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. Human, Mouse, Rat 반응성. Affinity chromatography 정제, PBS/glycerol buffer, -20°C 보관. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTF1 (Accession Q16619), corresponding to amino acid residues L33–V83 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852484 |
Product Specific Information
Antibody detects endogenous levels of total Cardiotrophin-1.
Target Information
Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, signaling through gp130 receptor complexes. gp130 forms complexes with various receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF, and IL-11.
Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and induces hypertrophy in cardiac myocytes in vitro.
It is a secreted protein expressed at high levels in myocardium during cardiogenesis and promotes proliferation and survival of embryonic cardiomyocytes, suggesting a role in gp130 activation during cardiac development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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