Thermo Fisher Scientific SPAG5 Monoclonal Antibody (OTI5B2), TrueMAB
인간 SPAG5 단백질(아미노산 1–297)을 인식하는 마우스 모노클로날 항체로, Western blot에 최적화되어 있습니다. 1 mg/mL 농도의 액상 제품이며, PBS/BSA/글리세롤 버퍼에 보존됩니다. 세포분열 및 염색체 안정성 연구용으로 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–297 of human SPAG5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein highly expressed in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, playing a crucial role in spindle formation and mitotic spindle regulation.
SPAG5 contributes to sister chromatid cohesion and separation, maintaining chromosome integrity. It forms homodimers with a long stalk and globular head domain, producing aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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