Thermo Fisher Scientific PXR Polyclonal Antibody
PXR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 사용 가능. Human 시료 반응성이 검증됨. 합성 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2–1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human NR1I2 (aa 108–157) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610048 |
Product Specific Information
Peptide sequence:
KKEMIMSDEA VEERRALIKR KKSERTGTQP LGVQGLTEEQ RMMIRELMDA
Sequence homology:
Human: 100%
Target Information
This gene product belongs to the nuclear receptor superfamily, whose members are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein acts as a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to its promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by compounds such as dexamethasone and rifampicin that induce CYP3A4 expression. Several alternatively spliced transcripts encoding different isoforms have been described, with some using non-AUG translation initiation codons. Additional transcript variants exist but have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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