Thermo Fisher Scientific CD44 Monoclonal Antibody (CVS18)

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC
• PE
• Request custom conjugation

Product Specific Information

Mouse anti-Horse CD11a/CD18 antibody, clone CVS18 recognizes equine CD44, a plasma membrane glycoprotein broadly expressed on the cell surface of leucocytes.

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain, and certain epithelial cells of the intestine and breast. Multiple isoforms exist, including the predominant CD44H isoform found in many normal tissues.
CD44 functions as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration. It is involved in lymphocyte activation, recirculation, and homing. CD44 expression can be upregulated in some carcinomas and may correlate with metastatic potential.
Expression is observed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Bone marrow myeloid cells and memory T cells express high levels of CD44, and peripheral B and T cells can upregulate CD44 in response to stimulation.
The CD44 gene undergoes complex alternative splicing, generating multiple functionally distinct isoforms. Disorders associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.