Thermo Fisher Scientific Human RAR gamma-2 (aa 13-28) Synthetic Peptide

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

-

Product Specifications

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

PEP-229 is a 16 amino acid synthetic peptide corresponding to amino acid residues 13-28 from human retinoic acid receptor gamma 2. The sequence of this peptide is (amino to carboxy terminus): R (13) R L Y G A A G P G A G L L R R (28).

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA3-814. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

Reconstitute with 0.1 mL of distilled water.

Target Information

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD.||The corresponding gene for the retinoic acid receptor gamma 2 is NR1B3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.