Thermo Fisher Scientific GRIK5 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total GRIK5.

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes.
Grik5, also known as kainate-preferring glutamate receptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik5 is highly homologous to the related ionotropic glutamate receptor Grik4 (KA1). Like Grik4, Grik5 does not form homomeric channels but instead forms heteromers with Grik2.
In Grik2- but not Grik1-deficient mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.