Thermo Fisher Scientific LGR7 Monoclonal Antibody (3E3)
LGR7 단백질을 표적으로 하는 Thermo Fisher Scientific의 3E3 클론 단일클론 항체. Western blot 및 ELISA에 적합. 인간 반응성, Mouse IgG2a 타입, 액상 형태로 제공. PBS 버퍼에 보존제 없이 -20°C에서 보관.
- 카탈로그번호
- H00059350-M01
- 판매단위
- pk
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Applications
- Western Blot (WB): 1–5 µg/mL
- ELISA: 3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E3 |
| Immunogen | LGR7 (NP_067647, 68–162 a.a.) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
WSMQFDKYFA SYYKMTSQYP FEAETPECLV GSVPVQCLCQ GLELDCDETN LRAVPSVSSN VTAMSLQWNL IRKLPPDCFK NYHDLQKLYL QNNKI
Target Information
LGR7 is a low-density lipoprotein receptor of 757 amino acids belonging to the G-protein coupled receptor 1 family with rhodopsin-like receptor activity. It has seven transmembrane regions, a cysteine-rich motif, 10 LRR domains, and 5 N-glycosylation sites in the N terminus.
Research reports show that LGR7 acts as a receptor for relaxins (RLN1 and RLN2), stimulating adenylate cyclase activation, substrate adhesion, and chemo-migratory capacity of mononuclear leukocytes.
LGR7 is critical for mediating these biological responses via RNA interference lentiviral short hairpin constructs. It is widely expressed in 86% of 15 primary EC tissue samples, including brain, kidney, testis, and endometrium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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