Thermo Fisher Scientific ALKBH2 Polyclonal Antibody
Thermo Fisher의 ALKBH2 Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 Rabbit IgG 항체로, Western blot과 ELISA에 적합합니다. 핵 내 ALKBH2 단백질 검출에 유용하며, 친화 크로마토그래피로 정제된 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–261 of human ALKBH2 (NP_0011388471) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.12 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806542 |
Product Specific Information
Immunogen sequence:
MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL TYTFSGLTLS PKPWIPVLER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV RKKVLAPRVN LTFRKILLTK K
Positive Samples: MCF7, HeLa, HepG2
Cellular Location: Nucleus
Target Information
The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repairing specific DNA lesions in single-stranded DNA. ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that could otherwise lead to cancer. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors, indicating their importance in cancer prevention. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme inhibited by nickel ions, suggesting a possible role in cancer development. Conversely, ALKBH2 mRNA and protein levels increase in glioma cells following Photofrin-mediated photodynamic therapy, implying that down-regulation of ALKBH2 may enhance therapeutic effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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