Thermo Fisher Scientific SIPA1 Polyclonal Antibody
Human SIPA1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)와 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 비접합 상태의 액상 형태로 제공. 연구용으로 Ras 관련 단백질 Rap1 및 Rap2의 GAP 활성 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SIPA1. Recombinant protein control fragment (Product #RP-97563). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647310 |
Product Specific Information
Immunogen sequence:
SPSGSEDKGN PAPELRASFL PRTLSLRNSI SRIMSEAGSG TLEDEWQAIS EIASTCNTIL ESLSREGQPI PESGDPKGTP KSDAEPEPGN LSEKVSHLES M
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 82%
Target Information
The product of this gene is a mitogen-induced GTPase activating protein.
It exhibits specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases.
This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed.
It is localized to the perinuclear region.
Two alternatively spliced variants encoding the same isoform have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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