Thermo Fisher Scientific AktS1/PRAS40 Polyclonal Antibody
AktS1/PRAS40 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 액상 시약으로 4°C에서 보관.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 and 256 of human AKT1 substrate 1 (proline-rich Akt substrate, 40 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Predicted to react with Mouse based on 100% sequence identity
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis after various cell death signals.
AKT1S1 (also known as PRAS40) is a proline-rich substrate of kinase AKT1 and is involved in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia.
It is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), which controls cell growth and cycle, and acts as a negative regulator of autophagy.
Treatment with insulin-like growth factor-1 (IGF1) can induce phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: A301-202A_PRAS40_Q96B36-1_Rabbit_PDP.jpeg)
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