Thermo Fisher Scientific UNC13B Polyclonal Antibody
UNC13B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UNC13B. Recombinant protein control fragment (Product #RP-93102). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649265 |
Product Specific Information
Immunogen sequence:
SQLSELDQYH EQDDDHRETD SIHSCHSSHS LSRDGQAGFG EQEKPLEVTG QAEKEAACEP KEMKEDATTH PP
Highest antigen sequence identity to orthologs:
- Mouse: 74%
- Rat: 69%
Target Information
UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of the readily releasable vesicle pool (RRP).
Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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