Thermo Fisher Scientific c-Mpl Recombinant Rabbit Monoclonal Antibody (ARC2257)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive Samples: A-549, Raji, THP-1, Mouse liver, Mouse spleen, Mouse heart, Rat liver
• Immunogen sequence:
  HRVLGQYLRD TAALSPPKAT VSDTCEEVEP SLLEILPKSS ERTPLPLCSS QAQMDYRRLQ PSCLGTMPLS VCPPMAESGS CCTTHIANHS YLPLSYWQQP

Target Information

In 1990, the oncogene v-mpl was identified from the murine myeloproliferative leukemia virus, capable of immortalizing bone marrow hematopoietic cells from different lineages.
In 1992, the human homologue c-mpl was cloned, encoding a protein homologous to members of the hematopoietic receptor superfamily. Anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.
The ligand for c-mpl, thrombopoietin, cloned in 1994, was shown to be the major regulator of megakaryocytopoiesis and platelet formation.
The protein encoded by c-mpl (CD110) consists of 635 amino acids with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice are severely thrombocytopenic, highlighting the essential role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Upon thrombopoietin binding, CD110 dimerizes, activating JAK, STAT, MAPK families, adaptor protein Shc, and receptor phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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