Thermo Fisher Scientific MST1 (STK4) Polyclonal Antibody
Human, Mouse, Rat에 반응하는 MST1(STK4) 폴리클로날 항체로 Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관. Hippo 신호경로 연구 및 세포사멸 관련 단백질 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MST1. Recombinant protein control fragment (Product # RP-91405) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644241 |
Product Specific Information
Immunogen sequence:
IEHDDTLPSQ LGTMVINAED EEEEGTMKRR DETMQPAKPS FLEYFEQKEK ENQINSFGKS VPGPLKNSSD WKIPQDGDYE FHighest antigen sequence identity to the following orthologs:
Mouse - 94%, Rat - 94%.
Target Information
STK4 (MST1) is a serine/threonine kinase involved in apoptosis. It induces chromatin condensation during apoptosis and functions as a stress-activated, pro-apoptotic kinase. Upon caspase cleavage, it translocates into the nucleus, triggering DNA fragmentation.
STK4 is a key component of the Hippo signaling pathway, crucial for organ size control and tumor suppression by limiting proliferation and promoting apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, activate LATS1/2, which then phosphorylate YAP1 and WWTR1/TAZ to inhibit their nuclear translocation.
This mechanism represses hepatocyte proliferation, prevents activation of adult liver stem cells, and inhibits tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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