Thermo Fisher Scientific SIRP alpha Polyclonal Antibody
Human SIRP alpha(CD172a)을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(Frozen)에 사용 가능. 1mg/mL 농도의 액상 형태이며 PBS buffer에 0.02% sodium azide 포함. 세포 신호 억제 및 CD47 상호작용 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
- View 1 publication
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide from C terminus of human SIRPa1 (SIRP alpha, CD172a; UniProt ID: P78324-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2188047 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
SIRP alpha acts as a substrate for several activated tyrosine kinases (EGFR, PDGFR, src, insulin receptor) and negatively regulates receptor tyrosine kinase-coupled signaling pathways.
Binding of SIRP alpha to CD47 leads to phosphorylation of ITIM motifs, recruiting SHP-1 and SHP-2 phosphatases.
This interaction inhibits macrophage phagocytosis and contributes to T cell and DC activation.
SIRP alpha regulates cellular responses to serum, growth factors, insulin, oncogenes, and adhesion, playing roles in physiological and pathological processes.
Cancer cells highly express CD47, activating SIRP alpha and inhibiting macrophage-mediated destruction of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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