Thermo Fisher Scientific AGC1 Monoclonal Antibody (2A8)
AGC1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse monoclonal antibody(클론 2A8). Western blot, ICC/IF, ELISA에 사용 가능하며, Human 시료에 반응. PBS buffer에 보관되며, -20°C에서 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A8 |
| Immunogen | AGC1 (NP_037359, 56 a.a. approximately 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PMHPVTTAPS TAPLAPRIKW SRVSKEKEVV LLVATEGRVR VNSAYQDKVS LPNYPAIPSD ATLEVQSLRS NDSGVYRCEV MHGIEDSEAT LEVVVKGIVF
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
It is a key structural component of the extracellular matrix in cartilage, providing resistance to compression. The human protein is approximately 2316 amino acids (~250 kDa) and can exist in multiple isoforms due to alternative splicing.
Aggrecan has a bottlebrush-like structure with chondroitin sulfate and keratan sulfate chains attached to its core. It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Fragments of aggrecan are released into synovial fluid during all stages of osteoarthritis due to cleavage by aggrecanase and MMPs.
Antibodies BC-3 and BC-4 can detect neo-epitopes generated by these enzymes (ARGSVXXX and XXXVDIPEN, respectively).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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