Thermo Fisher Scientific MAVS Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total VISA.

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein identified as a critical component in the IFN beta signaling pathway that recruits IRF-3 to RIG-I, leading to activation of NF-kappa-B.
MAVS interacts with other innate immune pathway components such as the TLR adapter protein TRIF, TRAF2, and TRAF6, as well as IKK-alpha, IKK-beta, and IKK-iota kinases through its C-terminal region.
Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.