Thermo Fisher Scientific ENOSF1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116
• Predicted reactivity: Pig (88%), Bovine (89%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

DNA methylation is a major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins containing a methyl-CpG binding domain (MBD).
Each of these proteins, except MBD3, binds specifically to methylated DNA. MECP2, MBD1, and MBD2 can repress transcription from methylated gene promoters.
Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensable in stem cells but essential for embryonic development. Mutations in MECP2 cause most cases of Rett syndrome, a progressive neurologic developmental disorder and a common cause of mental retardation in females.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.