Thermo Fisher Scientific RAB5A Polyclonal Antibody
RAB5A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB 및 IHC에 적합합니다. 마우스와 랫트 반응성이 있으며, 합성 펩타이드 면역원으로 제작되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of mouse Ras-related protein Rab-5A (RAB5A) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat.
- Specificity: RAB5A.
Target Information
RAB5 proteins are small GTPases that regulate intracellular membrane trafficking, including vesicle formation and fusion with target membranes. They cycle between inactive GDP-bound and active GTP-bound states, recruiting downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
RAB5A is essential for plasma membrane and early endosome fusion, regulates filopodia extension, and is required for the exosomal release of SDCBP, CD63, PDCD6IP, and syndecan. It also plays a role in the maturation of apoptotic cell-containing phagosomes, likely acting downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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