Thermo Fisher Scientific SERTAD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SERTAD1(Accession Q9UHV2), corresponding to amino acid residues G139-P189. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SERTAD1,uniProtId:Q9UHV2-1,ncbiNodeId:9606,antigenRange:139-189,antigenLength:236,antigenImageFileName:PA5-103167_SERTAD1_Q9UHV2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-103167_SERTAD1_Q9UHV2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2852537

Product Specific Information

Antibody detects endogenous levels of total SEI-1.

Target Information

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.