Thermo Fisher Scientific Caspase 7 Monoclonal Antibody (4D10B2)
인간 Caspase 7을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, Flow cytometry, ELISA 등 다양한 연구용 응용에 적합합니다. 단백질 G 정제, 1 mg/mL 농도, PBS 버퍼 및 sodium azide 포함. 단기 4°C, 장기 -20°C 보관.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D10B2 |
| Immunogen | Purified recombinant fragment of human CASP-7 (AA: 29–198) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091271 |
Target Information
Caspase 7 is part of a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. The apoptotic caspases are involved in programmed cell death, while inflammatory caspases are linked to immune responses. Caspase 7 acts as an executioner caspase, activated by initiator caspases, and cleaves cellular substrates leading to apoptosis. It shares homology with caspases 1 and 3 and the C. elegans protein CED-3. Alternative splicing of Caspase-7 mRNA produces three distinct isoforms, and its activity can be inhibited by XIAP expression. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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