Thermo Fisher Scientific TTBK2 Polyclonal Antibody
TTBK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. 인간 및 여러 종에서 높은 상동성을 보이며, 액상 형태로 제공되고 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific TTBK2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1.0 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human TTBK2 (aa 270–319) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690241 |
Product Specific Information
This target displays homology in the following species:
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increase resistance to the chemotherapeutic agent Sunitinib. Reduction of TTBK2 through the use of siRNA sensitizes these cell lines to Sunitinib, suggesting that TTBK2 can be used as a resistance marker as well as a potential target to overcome resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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