Thermo Fisher Scientific PHGDH Monoclonal Antibody (S2)

Thermo Fisher Scientific PHGDH Monoclonal Antibody (S2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of PHGDH protein:
MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ IPQATASMKD GKWERKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TIGYDPIISP EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP KGTIQVITQG TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA GLNVTTSHSP AAPGEQGFGE CLLAVALAGA PYQAVGLVQG TTPVLQGLNG AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT MIGLLAEAGV RLLSYQTSLV SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF

Target Information

PHGDH gene encodes an enzyme involved in the early steps of L-serine synthesis in animal cells.
L-serine is essential for D-serine and other amino acid synthesis.
The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity.
Mutations in this gene have been associated with congenital microcephaly, psychomotor retardation, and other symptoms.
Multiple alternatively spliced transcript variants exist, though full-length forms are not fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.