Thermo Fisher Scientific Nectin 2 Monoclonal Antibody (R2.525)
Human CD112 (Nectin-2) 인식하는 Mouse Monoclonal Antibody (Clone R2.525). Flow Cytometry, IHC(F), IP 등 다양한 응용 가능. 1.0 mg/mL 농도의 정제된 액상 형태. PBS 버퍼 및 sodium azide 포함, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R2.525 |
| Immunogen | Proprietary immunogen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2284684 |
Product Specific Information
Mouse anti-Human CD112 antibody, clone R2-525 recognizes CD112 (also known as Poliovirus Receptor Related 2, PRR2 or Nectin-2), a surface molecule homologous to CD155, the poliovirus receptor (Lopez et al., 1998).
PRR2 expression is restricted to the myelo-monocytic and megakaryocytic lineages and has also been detected on hematopoietic progenitors expressing CD34.
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and one Ig-like V-type domain.
It is a plasma membrane component of adherens junctions and serves as an entry receptor for certain mutant strains of herpes simplex virus and pseudorabies virus.
It plays a role in cell-to-cell viral spread.
Genetic variations in this gene are associated with differences in the severity of multiple sclerosis.
Alternate transcriptional splice variants encoding different isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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