Thermo Fisher Scientific Nectin 2 Monoclonal Antibody (R2.525)

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

-

Flow Cytometry (Flow)

1:50

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

R2.525

Immunogen

Proprietary immunogen.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

purified

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_2284684

Product Specific Information

Mouse anti Human CD112 antibody, clone R2-525 recognizes CD112, also known as Poliovirus Receptor Related 2, PRR2 or Nectin-2, a surface molecule originally reported to be homologous to CD155, the poliovirus receptor (Lopez et al. 1998). PRR2 expression is restricted to the myelo-monocytic and megakaryocytic lineages. PRR2 expression has also been detected on haematopoeitic progenitors expressing CD34.

Target Information

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.