Thermo Fisher Scientific THOC5 Polyclonal Antibody
인간 THOC5 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 Immunocytochemistry에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용 전용 제품으로 mRNA 수출 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human THOC5 (Accession Q13769), corresponding to amino acid residues I386–E436 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852463 |
Product Specific Information
Antibody detects endogenous levels of total THOC5.
Target Information
THOC5 is a component of the THO subcomplex of the TREX complex, which associates specifically with spliced mRNA. It binds to mRNA upstream of the exon-junction complex (EJC) and functions in mRNA export via interactions with THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and virus production. THOC5, together with THOC4, participates in NXF1-NXT1 mediated nuclear export of HSP70 mRNA and may be involved in granulocyte and adipocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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