Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI1D12), TrueMAB
인간 L1CAM 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western Blot, ICC/IF, Flow Cytometry에 적합합니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. 신경계 발달 및 CRASH 증후군 연구용으로 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D12 |
| Immunogen | Full length human recombinant protein of human L1CAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family.
The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain.
This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation.
Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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