Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
Thermo Fisher Scientific의 N4BP2L2 폴리클로날 항체는 인간 N4BP2L2 단백질의 내부 영역에서 유래한 합성 펩타이드를 면역원으로 제작되었습니다. Western blot에 최적화되어 있으며, 고순도 Rabbit IgG 형식으로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA539341
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human N4BP2L2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555932 |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is dramatically down-regulated after exposure to arsenic compounds, an event that precedes neutropenia.
PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, leading to decreased neutrophil counts and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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