Thermo Fisher Scientific IRF8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_0021541) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IRF8,uniProtId:Q02556-1,ncbiNodeId:9606,antigenRange:137-426,antigenLength:426,antigenImageFileName:PA5-89354_IRF8_Q02556-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89354_IRF8_Q02556-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805514

Product Specific Information

Immunogen sequence: ECGRSEIDEL IKEPSVDDYM GMIKRSPSPP EACRSQLLPD WWAQQPSTGV PLVTGYTTYD AHHSAFSQMV ISFYYGGKLV GQATTTCPEG CRLSLSQPGL PGTKLYGPEG LELVRFPPAD AIPSERQRQV TRKLFGHLER GVLLHSSRQG VFVKRLCQGR VFCSGNAVVC KGRPNKLERD EVVQVFDTSQ FFRELQQFYN SQGRLPDGRV VLCFGEEFPD MAPLRSKLIL VQIEQLYVRQ LAEEAGKSCG AGSVMQAPEE PPPDQVFRMF PDICASHQRS FFRENQQITV; Positive Samples: THP-1; Cellular Location: Nucleus

Target Information

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.