Thermo Fisher Scientific MED11 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000 dilution

Product Specifications

Product Specific Information

Predicted to react with Human and Rat samples.

Target Information

In mammalian cells, transcription is regulated by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex functions as a bridge between regulatory proteins and Pol II, regulating Pol II-dependent transcription.

Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and a component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes on chromosome 17—p53 and BRCA1—are associated with DNA repair and cancer predisposition. Malfunction or loss of p53 expression is linked to malignant cell growth and Li-Fraumeni syndrome, while BRCA1 mutations are related to ovarian, colon, prostate, and fallopian tube cancers.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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