Thermo Fisher Scientific MYOC Polyclonal Antibody
Human MYOC 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공. MYOC 유전자 연구 및 녹내장 관련 단백질 분석에 적합.
- 카탈로그번호
- PA555590
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MYOC. Recombinant protein control fragment (Product #RP-93985). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644381 |
Product Specific Information
Immunogen sequence:
NLLRDKSVLE EEKKRLRQEN ENLARRLESS SQEVARLRRG QCPQTRDTAR AVPPGSREVS TWNLDTLAFQ ELKSELTEVP ASRIL
Highest antigen sequence identity to the following orthologs:
- Mouse: 79%
- Rat: 79%
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. Myocilin can form homomultimers in vivo and also associate with extracellular matrix components via interactions with the Hep II domain of FibroPVRL1. It interacts with myosin regulatory light chain, suggesting a role in the actomyosin system and regulation of trabecular meshwork (TM) function, which controls intraocular pressure (IOP). Dysfunction of TM can lead to elevated IOP and glaucoma development.
MYOC (also known as TIGR) maps to chromosome 1q24.3 and mutations in this gene are linked to primary open-angle glaucoma (POAG), a major cause of blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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