Thermo Fisher Scientific CYR61 Polyclonal Antibody
CYR61 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며 PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYR61 (Accession O00622), corresponding to amino acid residues I199–T249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851762 |
Product Specific Information
Antibody detects endogenous levels of total CYR61/CCN1.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor-inducible immediate-early gene that associates with the extracellular matrix and connective tissue. It belongs to the CCN protein family, which includes CTGF and the mouse homolog Fisp12. CYR61 functions as an angiogenic inducer by binding to integrin αvβ3, stimulating cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Expression of CYR61 increases during vessel growth, wound healing, and chondrocyte differentiation, and is also observed in various tumors where it promotes tumor growth and serves as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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