Thermo Fisher Scientific FOXC1 Polyclonal Antibody
FOXC1 단백질을 인식하는 염소 유래 폴리클로날 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 합성 펩타이드 면역원 기반으로 제작되었으며, 고순도의 액상 형태로 제공. 인간 시료에 반응하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RTSGAFVYDCSKF) corresponding to the C-terminus amino acids of FOXC1 (aa 541–553) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982845 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
FOXC1 is a protein belonging to the forkhead family of transcription factors characterized by a distinct DNA-binding forkhead domain. Although its specific function is not fully understood, FOXC1 plays a role in regulating the FGF19–FGFR4–MAPK pathway, promoting the development and maintenance of anterior segment structures within the eye.
Mutations in this gene are associated with various ocular disorders, including glaucoma, iridogoniodysgenesis anomaly, and Peters anomaly, which involve corneal and iris developmental defects. Additionally, FOXC1 mutations are linked to Axenfeld-Rieger anomaly, characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth, and developmental delay.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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