Thermo Fisher Scientific NAB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunoprecipitation (IP)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Predicted reactivity: Mouse (93%), Rat (96%), Rhesus Monkey (100%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transcriptional control is regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). NAB1 and NAB2 are evolutionarily conserved corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain:

• N-terminal NAB conserved domain 1 (NCD1) for NGFI-A binding
• C-terminal NCD2 domain responsible for repressor function

NAB2 is mainly localized in the nucleus and may play a role in downregulating NGFI-A activity and controlling cell division, differentiation, and apoptosis.
It has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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