Thermo Fisher Scientific PALB2 Polyclonal Antibody, Biotin
PALB2 단백질을 인식하는 Biotin 결합 토끼 다클론 항체로, WB, IHC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. DNA 손상 복구 연구 및 BRCA 관련 암 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1,130–1,186 on human PALB2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and, like BRCA1 and BRCA2, is a breast cancer susceptibility gene. PALB2 functions by directly binding to BRCA1, allowing the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may allow predictions of tumor responsiveness to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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