Thermo Fisher Scientific ARAP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 834-1133 of human ARAP1 (NP_0011286621) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARAP1,uniProtId:Q96P48-6,ncbiNodeId:9606,antigenRange:834-1133,antigenLength:1450,antigenImageFileName:PA5-87923_ARAP1_Q96P48-6_Rabbit.svg,antigenImageFileNamePDP:PA5-87923_ARAP1_Q96P48-6_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.87 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804507

Product Specific Information

Immunogen sequence: SVDEEELRKQ REEITAIVKM RVAGTASGTQ HAGDFICTVY LEEKKAETEQ HIKVPASMTA EELTLEILDR RNVGIREKDY WTCFEVNERE EAERPLHFAE KVLPILHGLG TDSHLVVKKH QAMEAMLLYL ASRVGDTKHG MMKFREDRSL LGLGLPSGGF HDRYFILNSS CLRLYKEVRS HRPEKEWPIK SLKVYLGVKK KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV; Positive Samples: 293T, LO2, HeLa, Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Golgi stack membrane, Peripheral membrane protein

Target Information

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.