Thermo Fisher Scientific PARP16 Polyclonal Antibody
PARP16 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(P)에서 1:500 희석으로 사용 가능합니다. Protein A 정제, 1 mg/mL 농도의 액상 제품이며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PARP16 (amino acids 120–170) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells.
PARP16 is a member of the poly(ADP-ribose) polymerases (PARPs) family, encoded by different genes and displaying a conserved catalytic domain. Among this family, PARP-1 (113 kDa) and PARP-2 (62 kDa) are known to have catalytic activity immediately stimulated by DNA strand breaks.
The discovery of novel PARPs expands the understanding of poly(ADP-ribosyl)ation reactions in various aspects of cell biology, including cell proliferation and cell death. Some members interact with each other, share partners and subcellular localizations, suggesting fine-tuned regulation of this post-translational modification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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