Thermo Fisher Scientific PCID2 Polyclonal Antibody
Thermo Fisher Scientific의 PCID2 Polyclonal Antibody는 Rat에서 반응하는 Rabbit IgG 기반 항체로, WB에 사용 가능합니다. TREX-2 복합체 연구 및 B세포 생존 관련 단백질 분석에 적합하며, 고순도 Affinity chromatography로 정제된 액상 형태입니다.
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Thermo Fisher Scientific PCID2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of rat PCID2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689528 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
Target Information
PCID2 is required for B-cell survival through regulation of MAD2L1 expression during B cell differentiation. It is a component of the TREX-2 complex (transcription and export complex 2), composed of ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).
The TREX-2 complex functions in docking export-competent mRNPs to the nuclear pore complex and participates in mRNA export and chromatin positioning.
PCID2 binds and stabilizes BRCA2, contributing to control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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