Thermo Fisher Scientific Factor XIII B Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
EMKWKYEGKV LHGDLIDFVC KQGYDLSPLT PLSELSVQCN RGEVKYPLCT RKESKGMCTS PPLIKHGVII SSTVDTYENG SSVEYRCFDH HFLEGSREAY CLDGMWTTPP LCLEPCTLSF TEMEKNNLLL KWDFDNRPHI LHGEY

• Highest antigen sequence identity to orthologs:
  • Mouse: 76%
  • Rat: 74%

Target Information

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules without enzymatic activity. Platelet factor XIII consists only of two A subunits identical to plasma origin. Upon activation by thrombin cleavage and calcium presence, plasma factor XIII dissociates its B subunits to yield the active enzyme factor XIIIa, which catalyzes gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the clot.
Factor XIII deficiency is classified as:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit only
  These defects can cause lifelong bleeding tendency, impaired wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.