ELK Biotechnology Recombinant 2019-nCoV S protein RBD(C-mFc)
SARS-CoV-2 스파이크 단백질 RBD 영역을 포유류 세포에서 발현한 재조합 단백질. C-말단 mFc 태그 포함. 95% 이상 순도, ACE2 결합 활성 검증. PBS(pH 7.4) 용액 형태로 공급되며, -20°C 이하 보관.
- 카테고리
- Protein
- 판매단위
- pk
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Recombinant 2019-nCoV S protein RBD (C-mFc)
제품 설명
Recombinant SARS-CoV-2 S protein RBD는 포유류 세포 발현 시스템을 통해 생산된 단백질로, Asn331~Val524 영역을 포함하며 C-말단에 mFc 태그가 결합되어 있습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | Recombinant 2019-nCoV S protein RBD (C-mFc) |
| Description | Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Asn331-Val524 is expressed with a mFc tag at the C-terminus. |
| Expression Host | Human Cells |
| Accession | QHD43416.1 |
| Molecular weight | 47.9 kDa |
| Apparent molecular weight | 50–60 kDa (reducing conditions) |
| Other names | S protein RBD; 2019-nCoV S protein RBD |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE |
| Biological activity | Immobilized Human ACE-2-His (Cat#C419) at 10 μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-mFc (Cat#DRA32). The ED50 of 2019-nCoV S Protein RBD-mFc (Cat#DRA32) is 19.90 ng/ml. |
| Storage | Reconstituted protein solution should be stored at ≤ -20°C |
| Delivery condition | Shipped on dry ice pack. Upon receipt, store immediately at the temperature listed below. |
Background
The spike (S) glycoprotein of coronaviruses is essential for viral binding to host cells during infection initiation. The SARS-CoV spike (S) glycoprotein mediates membrane fusion required for virus entry and cell fusion, serving as a major immunogen and a target for entry inhibitors.
2019-nCoV infects human respiratory epithelial cells via interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein composed of two subunits, S1 and S2. S1 contains the receptor-binding domain (RBD) responsible for receptor recognition, while S2 contains elements required for membrane fusion.
The S protein plays key roles in inducing neutralizing antibodies, T-cell responses, and protective immunity.
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