ELK Biotechnology CK19 Mouse mAb
CK19 단백질을 인식하는 Mouse 단일클론 항체로, Human, Rat, Mouse 시료에서 IHC에 사용 가능. 간 전이 및 유방암 조직 구분에 유용. 고순도 IgG1 형태로 안정적이며 -20°C 보관 시 장기 보존 가능.
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ELK Biotechnology CK19 Mouse mAb
제품 개요
CK19 Mouse 단일클론 항체는 Cytokeratin 19(KRT19)를 인식하며, Human, Rat, Mouse 조직에서 반응합니다. 본 항체는 IHC 실험에 최적화되어 있으며 간 전이 및 유방암 조직 구분에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CK19 Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Alternative Names | Cytokeratin 19, K19, K1CS, keratin 19, KRT19 |
| Source | Mouse |
| Applications | IHC |
| Recommended dilutions | IHC 1:200 |
| Immunogen | Synthetic Peptide |
| Storage | PBS with 0.02% sodium azide and 50% glycerol, pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1 mg/ml |
| Observed band | 44 kDa |
| GeneID (Human) | 3880 |
| Human Swiss-Prot No | P08727 |
| Cellular localization | Cytoskeleton, Cytosol |
Background
This protein is a member of the keratin family. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Keratin 19 is not expressed in hepatocytes, therefore, antibody to keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.
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