Thermo Fisher Scientific FNTA Polyclonal Antibody
Thermo Fisher Scientific의 FNTA Polyclonal Antibody는 인간 FNTA 단백질을 인식하는 토끼 다클론 항체입니다. Western blot, IHC, ICC/IF에 적합하며 고순도의 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FNTA. Recombinant protein control fragment (Product #RP-101897) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641708 |
Product Specific Information
Immunogen sequence:
LDSPSYVLYR HFRRVLLKSL QKDLHEEMNY ITAIIEEQPK NYQVWHHRRV LVEWLRDPSQ ELEFIADI
Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 84%
Target Information
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).
Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these is the CAAX farnesyl transferase (EC 2.5.1.21), an alpha-beta heterodimeric enzyme that catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box.
FNTA, the alpha subunit of farnesyl transferase, is shared by geranyl-geranyl protein transferases. In addition to transferring farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports indicate that FNTA interacts with TGF-beta and activin-type I receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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